Interferon: The 50th Anniversary

Front Matter....Pages i-ix
Front Matter....Pages 1-1
How to Chase a Red Herring and Come up with a Smallmouth Bass....Pages 3-7
Interferon Research BC (Before Cloning)....Pages 9-22
Purification and Cloning of Interferon Alpha....Pages 23-37
Front Matter....Pages 39-39
Type I Interferon: The Ever Unfolding Story....Pages 41-70
The Receptor of the Type I Interferon Family....Pages 71-95
IFN-γ: Recent Advances in Understanding Regulation of Expression, Biological Functions, and Clinical Applications....Pages 97-117
Cell Type-Specific Signaling in Response to Interferon-γ....Pages 119-154
Interferon Research: Impact on Understanding Transcriptional Control....Pages 155-163
Front Matter....Pages 165-165
TLR-Mediated Activation of Type I IFN During Antiviral Immune Responses: Fighting the Battle to Win the War....Pages 167-192
Regulation of Antiviral Innate Immune Responses by RIG-I Family of RNA Helicases....Pages 193-205
Beyond Double-Stranded RNA-Type I IFN Induction by 3pRNA and Other Viral Nucleic Acids....Pages 207-230
Front Matter....Pages 231-231
The Interferon-Stimulated Genes: Targets of Direct Signaling by Interferons, Double-Stranded RNA, and Viruses....Pages 233-250
Structure and Function of the Protein Kinase R....Pages 253-292
Front Matter....Pages 293-293
Viral Regulation and Evasion of the Host Response....Pages 295-313
Pathogenic Viruses: Smart Manipulators of the Interferon System....Pages 315-334
Front Matter....Pages 335-335
Type I Interferon During Viral Infections: Multiple Triggers for a Multifunctional Mediator....Pages 337-357
Type I Interferon in Systemic Lupus Erythematosus....Pages 359-386
Back Matter....Pages 387-391